| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 3 |
|---|
| Ligand | BDBM50583973 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2158673 (CHEMBL5043423) |
|---|
| Ki | 211±n/a nM |
|---|
| Citation |  Bata, N; Chaikuad, A; Bakas, NA; Limpert, AS; Lambert, LJ; Sheffler, DJ; Berger, LM; Liu, G; Yuan, C; Wang, L; Peng, Y; Dong, J; Celeridad, M; Layng, F; Knapp, S; Cosford, NDP Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. J Med Chem65:1352-1369 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase 3 |
|---|
| Name: | Serine/threonine-protein kinase 3 |
|---|
| Synonyms: | KRS1 | MST-2 | MST2 | Mammalian STE20-like protein kinase 2 | STE20-Like Kinase MST2 | STK3 | STK3_HUMAN | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase 3 (MST2) | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase Krs-1 | Serine/threonine-protein kinase MST2 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 56284.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 491 |
|---|
| Sequence: | MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE
DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT
VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT
FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK
RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES
DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM
SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA
MDAKKRRQQNF
|
|
|
|---|
| BDBM50583973 |
|---|
| n/a |
|---|
| Name | BDBM50583973 |
|---|
| Synonyms: | CHEMBL5093114 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H16ClN3O |
|---|
| Mol. Mass. | 313.781 |
|---|
| SMILES | Clc1cccc(c1)-c1c[nH]c2nccc(N3CCOCC3)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
