| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50153823 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305841 (CHEMBL829582) |
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| IC50 | 340±n/a nM |
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| Citation |  Brown, DS; Belfield, AJ; Brown, GR; Campbell, D; Foubister, A; Masters, DJ; Pike, KG; Snelson, WL; Wells, SL A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis. Bioorg Med Chem Lett14:5383-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50153823 |
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| n/a |
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| Name | BDBM50153823 |
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| Synonyms: | CHEMBL184347 | N-[2-Bromo-5-(3-dimethylamino-benzoylamino)-phenyl]-3,4-dimethoxy-benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24BrN3O4 |
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| Mol. Mass. | 498.369 |
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| SMILES | COc1ccc(cc1OC)C(=O)Nc1cc(NC(=O)c2cccc(c2)N(C)C)ccc1Br |
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| Structure | 
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