| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
|---|
| Ligand | BDBM50153930 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305948 (CHEMBL832788) |
|---|
| IC50 | 19000±n/a nM |
|---|
| Citation |  Imai, M; Shiota, T; Kataoka, K; Tarby, CM; Moree, WJ; Tsutsumi, T; Sudo, M; Ramirez-Weinhouse, MM; Comer, D; Sun, CM; Yamagami, S; Tanaka, H; Morita, T; Hada, T; Greene, J; Barnum, D; Saunders, J; Myers, PL; Kato, Y; Endo, N Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives. Bioorg Med Chem Lett14:5407-11 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 2 |
|---|
| Name: | C-C chemokine receptor type 2 |
|---|
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41932.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41597 |
|---|
| Residue: | 374 |
|---|
| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
|
|
|
|---|
| BDBM50153930 |
|---|
| n/a |
|---|
| Name | BDBM50153930 |
|---|
| Synonyms: | 1-(3,3-Diphenyl-propyl)-4-(4-nitro-benzyl)-[1,4]diazepane | CHEMBL184688 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H31N3O2 |
|---|
| Mol. Mass. | 429.5539 |
|---|
| SMILES | [O-][N+](=O)c1ccc(CN2CCCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
