Reaction Details |
| Report a problem with these data |
Target | Caspase-2 |
---|
Ligand | BDBM480973 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2162877 (CHEMBL5047738) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Casimiro-Garcia, A; Allais, C; Brennan, A; Choi, C; Dower, G; Farley, KA; Fleming, M; Flick, A; Frisbie, RK; Hall, J; Hepworth, D; Jones, H; Knafels, JD; Kortum, S; Lovering, FE; Mathias, JP; Mohan, S; Morgan, PM; Parng, C; Parris, K; Pullen, N; Schlerman, F; Stansfield, J; Strohbach, JW; Vajdos, FF; Vincent, F; Wang, H; Wang, X; Webster, R; Wright, SW Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem65:757-784 (2022) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Caspase-2 |
---|
Name: | Caspase-2 |
Synonyms: | CASP-2 | CASP2 | CASP2_HUMAN | Caspase-2 subunit p12 | Caspase-2 subunit p13 | Caspase-2 subunit p18 | ICH-1 protease | ICH-1L/1S | ICH1 | NEDD-2 | NEDD2 | Neural precursor cell expressed developmentally down-regulated protein 2 |
Type: | Enzyme |
Mol. Mass.: | 50688.29 |
Organism: | Homo sapiens (Human) |
Description: | P42575 |
Residue: | 452 |
Sequence: | MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT
TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT
PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV
HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF
DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT
RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY
APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
|
|
|
BDBM480973 |
---|
n/a |
---|
Name | BDBM480973 |
Synonyms: | US10906888, Example 190 |
Type | Small organic molecule |
Emp. Form. | C17H20N6O |
Mol. Mass. | 324.3803 |
SMILES | O=C(N1CCCCC1)c1cnc(NC2(CC2)c2cncnc2)nc1 |
Structure |
|