Reaction Details |
| Report a problem with these data |
Target | Beta-secretase 2 |
---|
Ligand | BDBM50587074 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2170796 (CHEMBL5055930) |
---|
IC50 | 2.0±n/a nM |
---|
Citation | Rueeger, H; Lueoend, R; Machauer, R; Veenstra, SJ; Holzer, P; Hurth, K; Voegtle, M; Frederiksen, M; Rondeau, JM; Tintelnot-Blomley, M; Jacobson, LH; Staufenbiel, M; Laue, G; Neumann, U Synthesis of the Potent, Selective, and Efficacious ?-Secretase (BACE1) Inhibitor NB-360. J Med Chem64:4677-4696 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Beta-secretase 2 |
---|
Name: | Beta-secretase 2 |
Synonyms: | AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2) |
Type: | Protein |
Mol. Mass.: | 56171.20 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5Z0 |
Residue: | 518 |
Sequence: | MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
|
|
|
BDBM50587074 |
---|
n/a |
---|
Name | BDBM50587074 |
Synonyms: | CHEMBL5085959 |
Type | Small organic molecule |
Emp. Form. | C19H16Cl2F4N4O2 |
Mol. Mass. | 479.256 |
SMILES | C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F |r,c:7| |
Structure |
|