| Reaction Details |
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 | Report a problem with these data |
| Target | Hematopoietic prostaglandin D synthase |
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| Ligand | BDBM50587270 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2172000 (CHEMBL5057134) |
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| IC50 | 170±n/a nM |
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| Citation |  Yokoo, H; Shibata, N; Endo, A; Ito, T; Yanase, Y; Murakami, Y; Fujii, K; Hamamura, K; Saeki, Y; Naito, M; Aritake, K; Demizu, Y Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design. J Med Chem64:15868-15882 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hematopoietic prostaglandin D synthase |
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| Name: | Hematopoietic prostaglandin D synthase |
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| Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23341.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
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| Residue: | 199 |
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| Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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| BDBM50587270 |
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| n/a |
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| Name | BDBM50587270 |
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| Synonyms: | CHEMBL5076100 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H38N8O7 |
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| Mol. Mass. | 742.7791 |
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| SMILES | O=C(Nc1ccc(cc1)N1CCC(CC1)C(=O)N1CCN(CC1)c1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1cnc(Oc2ccccc2)nc1 |
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| Structure | 
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