| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 4 |
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| Ligand | BDBM50159213 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306161 (CHEMBL874557) |
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| IC50 | 4.5±n/a nM |
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| Citation |  Tamamura, H; Hiramatsu, K; Ueda, S; Wang, Z; Kusano, S; Terakubo, S; Trent, JO; Peiper, SC; Yamamoto, N; Nakashima, H; Otaka, A; Fujii, N Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem48:380-91 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 4 |
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| Name: | C-X-C chemokine receptor type 4 |
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| Synonyms: | C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4) | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | CXCR4_HUMAN | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 39754.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P61073 |
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| Residue: | 352 |
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| Sequence: | MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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| BDBM50159213 |
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| n/a |
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| Name | BDBM50159213 |
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| Synonyms: | CHEMBL370001 | N-{3-[10-(3-Guanidino-propyl)-4-(4-hydroxy-benzyl)-13-naphthalen-2-ylmethyl-2,5,8,11,14-pentaoxo-1,3,6,9,12pentaaza-cyclotetradec-7-yl]-propyl}-guanidine | N-{3-[5-(3-Guanidino-propyl)-11-(4-hydroxy-benzyl)-2-naphthalen-2-ylmethyl-4,7,10,13,14-pentaoxo-1,3,6,9,12pentaaza-cyclotetradec-8-yl]-propyl}-guanidine |
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| Type | Small organic molecule |
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| Emp. Form. | C35H45N11O6 |
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| Mol. Mass. | 715.8019 |
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| SMILES | NC(=N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O |
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| Structure | 
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