| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50410085 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303515 (CHEMBL839629) |
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| Ki | 2.3±n/a nM |
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| Citation |  Guo, Z; Wu, D; Zhu, YF; Tucci, FC; Pontillo, J; Saunders, J; Xie, Q; Struthers, RS; Chen, C A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists. Bioorg Med Chem Lett15:693-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37749.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30968 |
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| Residue: | 328 |
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| Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50410085 |
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| n/a |
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| Name | BDBM50410085 |
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| Synonyms: | CHEMBL2113012 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24F2N4O3 |
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| Mol. Mass. | 466.4799 |
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| SMILES | COc1cccc(c1)N1CN(Cc2c(F)cccc2F)C(=O)N(C[C@H](N)c2ccccc2)C1=O |
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| Structure | 
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