Reaction Details |
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Target | Histamine H1 receptor |
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Ligand | BDBM50156867 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305389 (CHEMBL833040) |
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IC50 | 190±n/a nM |
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Citation | Fonquerna, S; Miralpeix, M; Pagès, L; Puig, C; Cardús, A; Antón, F; Vilella, D; Aparici, M; Prieto, J; Warrellow, G; Beleta, J; Ryder, H Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists. Bioorg Med Chem Lett15:1165-7 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H1 receptor |
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Name: | Histamine H1 receptor |
Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55641.53 |
Organism: | Cavia porcellus (domestic guinea pig) |
Description: | Guinea pig cerebellum was used in binding assay. |
Residue: | 488 |
Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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BDBM50156867 |
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n/a |
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Name | BDBM50156867 |
Synonyms: | 2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperidin-1-yl}-ethoxy)-benzoic acid | 2-(2-{4-[1-(2-ethoxyethyl)-1H-indol-3-yl]piperidin-1-yl}ethoxy)benzoic acid | CHEMBL183706 |
Type | Small organic molecule |
Emp. Form. | C26H32N2O4 |
Mol. Mass. | 436.5433 |
SMILES | CCOCCn1cc(C2CCN(CCOc3ccccc3C(O)=O)CC2)c2ccccc12 |
Structure |
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