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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Growth hormone secretagogue receptor type 1 | ||
| Ligand | BDBM50161042 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306206 (CHEMBL830164) | ||
| IC50 | 860.0±n/a nM | ||
| Citation |  Xin, Z; Zhao, H; Serby, MD; Liu, B; Schaefer, VG; Falls, DH; Kaszubska, W; Colins, CA; Sham, HL; Liu, G Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists. Bioorg Med Chem Lett15:1201-4 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Growth hormone secretagogue receptor type 1 | |||
| Name: | Growth hormone secretagogue receptor type 1 | ||
| Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) | ||
| Type: | Receptor | ||
| Mol. Mass.: | 41334.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. | ||
| Residue: | 366 | ||
| Sequence: |
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| BDBM50161042 | |||
| n/a | |||
| Name | BDBM50161042 | ||
| Synonyms: | 3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [2-(azepane-1-carbonyl)-phenyl]-amide | CHEMBL436275 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23Cl2N3O3 | ||
| Mol. Mass. | 472.364 | ||
| SMILES | Cc1onc(c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1)-c1c(Cl)cccc1Cl |(-2.05,1.99,;-3,.78,;-4.53,.86,;-5.07,-.57,;-3.88,-1.52,;-2.6,-.68,;-1.14,-1.08,;-.74,-2.57,;-.05,,;1.44,-.38,;2.21,-1.68,;3.77,-1.68,;4.51,-.33,;3.72,.99,;2.19,.97,;2.19,2.5,;1.09,3.6,;3.26,3.6,;2.74,5.06,;3.56,6.36,;5.09,6.55,;6.19,5.46,;6.02,3.92,;4.72,3.09,;-3.79,-3.05,;-2.44,-3.75,;-.95,-4.16,;-2.35,-5.31,;-3.63,-6.14,;-5,-5.43,;-5.09,-3.91,;-6.47,-3.23,)| | ||
| Structure | 
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