Citation | Tucci, FC; Zhu, YF; Struthers, RS; Guo, Z; Gross, TD; Rowbottom, MW; Acevedo, O; Gao, Y; Saunders, J; Xie, Q; Reinhart, GJ; Liu, XJ; Ling, N; Bonneville, AK; Chen, T; Bozigian, H; Chen, C 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization. J Med Chem48:1169-78 (2005) [PubMed] Article |
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SMILES | COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)C(C)C)c1=O |wU:26.28,(4.12,9.96,;2.78,9.19,;2.78,7.65,;4.12,6.88,;4.12,5.33,;2.78,4.57,;1.45,5.34,;1.45,6.88,;.12,7.65,;.1,4.59,;.1,3.05,;1.43,2.28,;-1.23,2.26,;-1.23,.72,;.1,-.05,;.1,-1.6,;-1.24,-2.37,;1.43,-2.37,;2.76,-1.6,;2.76,-.05,;1.43,.72,;2.52,1.82,;-2.56,3.04,;-3.9,2.28,;-2.56,4.59,;-3.89,5.37,;-5.23,4.59,;-6.56,5.37,;-5.23,3.05,;-6.58,2.28,;-4.84,1.57,;-1.23,5.37,;-1.21,6.91,)| |