| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50162116 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306651 (CHEMBL832988) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Souers, AJ; Gao, J; Brune, M; Bush, E; Wodka, D; Vasudevan, A; Judd, AS; Mulhern, M; Brodjian, S; Dayton, B; Shapiro, R; Hernandez, LE; Marsh, KC; Sham, HL; Collins, CA; Kym, PR Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity. J Med Chem48:1318-21 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50162116 |
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| n/a |
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| Name | BDBM50162116 |
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| Synonyms: | 2-(4-(benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-6-yl)acetamide | 2-(4-Benzyloxy-phenyl)-N-[1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]-acetamide | CHEMBL179501 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30N4O2 |
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| Mol. Mass. | 454.5634 |
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| SMILES | O=C(Cc1ccc(OCc2ccccc2)cc1)Nc1ccc2cnn(CCN3CCCC3)c2c1 |
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| Structure | 
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