| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 26A1 |
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| Ligand | BDBM50176808 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305304 (CHEMBL832851) |
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| IC50 | 6000±n/a nM |
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| Citation |  Mulvihill, MJ; Kan, JL; Beck, P; Bittner, M; Cesario, C; Cooke, A; Keane, DM; Nigro, AI; Nillson, C; Smith, V; Srebernak, M; Sun, FL; Vrkljan, M; Winski, SL; Castelhano, AL; Emerson, D; Gibson, N Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs). Bioorg Med Chem Lett15:1669-73 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 26A1 |
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| Name: | Cytochrome P450 26A1 |
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| Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56216.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43174 |
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| Residue: | 497 |
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| Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
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| BDBM50176808 |
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| n/a |
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| Name | BDBM50176808 |
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| Synonyms: | 5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benzoimidazole | 6-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole | CHEMBL389433 | US9138393, Liarizole hydrochloride | US9144538, Liarizole hydrochloride | liarozole |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13ClN4 |
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| Mol. Mass. | 308.765 |
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| SMILES | Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 |
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| Structure | 
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