| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50165867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305410 (CHEMBL833059) |
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| IC50 | 1700±n/a nM |
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| Citation |  Laughlin, SK; Clark, MP; Djung, JF; Golebiowski, A; Brugel, TA; Sabat, M; Bookland, RG; Laufersweiler, MJ; VanRens, JC; Townes, JA; De, B; Hsieh, LC; Xu, SC; Walter, RL; Mekel, MJ; Janusz, MJ The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Bioorg Med Chem Lett15:2399-403 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50165867 |
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| n/a |
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| Name | BDBM50165867 |
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| Synonyms: | 2-Ethoxymethyl-4-(4-fluoro-phenyl)-3-[2-((R)-1-phenyl-ethylamino)-pyrimidin-4-yl]-2H-isoxazol-5-one | CHEMBL366003 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23FN4O3 |
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| Mol. Mass. | 434.4628 |
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| SMILES | CCOCn1oc(=O)c(c1-c1ccnc(N[C@H](C)c2ccccc2)n1)-c1ccc(F)cc1 |
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| Structure | 
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