| Reaction Details |
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 | Report a problem with these data |
| Target | NT-3 growth factor receptor |
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| Ligand | BDBM50593027 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2206796 (CHEMBL5119504) |
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| IC50 | 6.9±n/a nM |
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| Citation |  Ito, T; Kinoshita, K; Tomizawa, M; Shinohara, S; Nishii, H; Matsushita, M; Hattori, K; Kohchi, Y; Kohchi, M; Hayase, T; Watanabe, F; Hasegawa, K; Tanaka, H; Kuramoto, S; Takanashi, K; Oikawa, N Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor. J Med Chem65:12427-12444 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NT-3 growth factor receptor |
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| Name: | NT-3 growth factor receptor |
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| Synonyms: | GP145-TrkC | NTRK3 | NTRK3_HUMAN | Neurotrophic tyrosine kinase receptor | Neurotrophic tyrosine kinase receptor type 3 | TRKC | Trk-C | TrkC tyrosine kinase | Tyrosine kinase receptor C (Trk-C) |
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| Type: | Enzyme |
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| Mol. Mass.: | 94428.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16288 |
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| Residue: | 839 |
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| Sequence: | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF
CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
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| BDBM50593027 |
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| n/a |
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| Name | BDBM50593027 |
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| Synonyms: | CHEMBL5186340 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H34N2O5 |
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| Mol. Mass. | 562.6549 |
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| SMILES | CC1(C)c2oc3cc(ccc3c2C(=O)c2ccc(OCCN3CCOCC3)cc12)C#Cc1cc(OCC2CC2)ccn1 |
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| Structure | 
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