| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
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| Ligand | BDBM50513743 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2207797 (CHEMBL5120505) |
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| IC50 | 8100±n/a nM |
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| Citation |  Yamada, M; Hirose, Y; Lin, B; Fumimoto, M; Nunomura, K; Natchanun, S; Takahashi, N; Ohki, Y; Sako, M; Murai, K; Harada, K; Arai, M; Suzuki, S; Nakamura, T; Haruta, J; Arisawa, M Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of ACS Med Chem Lett13:1582-1590 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] A |
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| Name: | Amine oxidase [flavin-containing] A |
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| Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) |
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| Type: | Protein |
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| Mol. Mass.: | 59689.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21397 |
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| Residue: | 527 |
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| Sequence: | MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
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| BDBM50513743 |
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| n/a |
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| Name | BDBM50513743 |
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| Synonyms: | CHEMBL4438605 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27NO5 |
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| Mol. Mass. | 385.4535 |
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| SMILES | COc1cc2CCN(CCCOc3ccc(C(C)=O)c(O)c3)Cc2cc1OC |
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| Structure | 
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