| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
|---|
| Ligand | BDBM50166502 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304763 (CHEMBL829360) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Kutterer, KM; Davis, JM; Singh, G; Yang, Y; Hu, W; Severin, A; Rasmussen, BA; Krishnamurthy, G; Failli, A; Katz, AH 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett15:2527-31 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
|---|
| Name: | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
|---|
| Synonyms: | EPT | Enoylpyruvate transferase | MURA_ECOLI | MurA (E. coli) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA | murZ |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 44814.62 |
|---|
| Organism: | Escherichia coli K-12 (Enterobacteria) |
|---|
| Description: | E. coli MurA |
|---|
| Residue: | 419 |
|---|
| Sequence: | MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL
GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR
PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT
IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV
AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP
AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL
SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
|
|
|
|---|
| BDBM50166502 |
|---|
| n/a |
|---|
| Name | BDBM50166502 |
|---|
| Synonyms: | 1,2-Bis-(4-chloro-phenyl)-5-[2-(2,4-difluoro-phenyl)-2-oxo-ethoxy]-4-methyl-pyrazolidin-3-one | CHEMBL363203 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H18Cl2F2N2O3 |
|---|
| Mol. Mass. | 491.314 |
|---|
| SMILES | CC1C(OCC(=O)c2ccc(F)cc2F)N(N(C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
