Reaction Details | |||
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Target | Gonadotropin-releasing hormone receptor | ||
Ligand | BDBM50168698 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_303748 (CHEMBL829791) | ||
Ki | 20±n/a nM | ||
Citation | Guo, Z; Wu, D; Zhu, YF; Tucci, FC; Regan, CF; Rowbottom, MW; Struthers, RS; Xie, Q; Reijmers, S; Sullivan, SK; Sai, Y; Chen, C Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists. Bioorg Med Chem Lett15:3685-90 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Gonadotropin-releasing hormone receptor | |||
Name: | Gonadotropin-releasing hormone receptor | ||
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) | ||
Type: | Enzyme | ||
Mol. Mass.: | 37749.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P30968 | ||
Residue: | 328 | ||
Sequence: |
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BDBM50168698 | |||
n/a | |||
Name | BDBM50168698 | ||
Synonyms: | 1-[2-Amino-2-(2-fluoro-phenyl)-ethyl]-3-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione | CHEMBL176056 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H20F4N4O4 | ||
Mol. Mass. | 516.4443 | ||
SMILES | COc1cccc(c1F)-n1c(=O)n(CC(N)c2ccccc2F)c(=O)n(Cc2c(F)cccc2F)c1=O |(8.06,2.56,;6.73,1.79,;6.73,.25,;8.07,-.52,;8.07,-2.08,;6.73,-2.85,;5.4,-2.08,;5.4,-.54,;4.07,.23,;4.07,-2.85,;2.74,-2.08,;2.74,-.54,;1.4,-2.85,;.07,-2.08,;-1.28,-2.83,;-1.28,-4.37,;-2.61,-2.06,;-3.92,-2.85,;-5.25,-2.08,;-5.27,-.54,;-3.92,.23,;-2.59,-.54,;-1.25,.23,;1.4,-4.39,;.07,-5.16,;2.74,-5.16,;2.73,-6.7,;4.07,-7.47,;5.39,-6.7,;4.04,-5.93,;6.72,-7.45,;6.73,-9.01,;5.39,-9.78,;4.06,-9.01,;2.71,-9.76,;4.07,-4.39,;5.4,-5.16,)| | ||
Structure |