| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Ligand | BDBM50596051 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2219157 (CHEMBL5132491) |
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| IC50 | 570±n/a nM |
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| Citation |  Prakash, M; Itoh, Y; Fujiwara, Y; Takahashi, Y; Takada, Y; Mellini, P; Elboray, EE; Terao, M; Yamashita, Y; Yamamoto, C; Yamaguchi, T; Kotoku, M; Kitao, Y; Singh, R; Roy, R; Obika, S; Oba, M; Wang, DO; Suzuki, T Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach. J Med Chem64:15810-15824 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58263.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1515854 |
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| Residue: | 505 |
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| Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
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| BDBM50596051 |
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| n/a |
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| Name | BDBM50596051 |
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| Synonyms: | CHEMBL5183243 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16Cl2N6O6 |
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| Mol. Mass. | 531.305 |
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| SMILES | OC(=O)\C=C\C(=O)NNC(=O)c1cnccc1Nc1cc(Cl)c(Nc2ccccc2[N+]([O-])=O)c(Cl)c1 |
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| Structure | 
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