Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50171322 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_303781 (CHEMBL830138) | ||
Ki | 5.1±n/a nM | ||
Citation | Guo, Z; Tellew, JE; Gross, RS; Dyck, B; Grey, J; Haddach, M; Kiankarimi, M; Lanier, M; Li, BF; Luo, Z; McCarthy, JR; Moorjani, M; Saunders, J; Sullivan, R; Zhang, X; Zamani-Kord, S; Grigoriadis, DE; Crowe, PD; Chen, TK; Williams, JP Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists. J Med Chem48:5104-7 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50171322 | |||
n/a | |||
Name | BDBM50171322 | ||
Synonyms: | 1-(2,4-Dichloro-phenyl)-7-methyl-5-(1-propyl-butyl)-4,5-dihydro-1H,3H-1,2a,5,8-tetraaza-acenaphthylen-2-one | CHEMBL190488 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H26Cl2N4O | ||
Mol. Mass. | 433.374 | ||
SMILES | CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(Cl)cc1Cl)c2=O |(2.62,5.41,;2.62,3.85,;1.29,3.08,;1.27,1.53,;-.06,.76,;-1.39,1.53,;-2.73,.76,;2.62,.75,;3.96,1.52,;5.29,.75,;5.28,-.79,;3.95,-1.57,;2.62,-.8,;1.29,-1.57,;1.29,-3.12,;-.2,-3.56,;3.14,-4.12,;4.28,-3.08,;5.82,-3.23,;6.78,-4.44,;6.22,-5.86,;7.2,-7.06,;8.71,-6.83,;9.68,-8.02,;9.26,-5.4,;8.3,-4.21,;8.86,-2.76,;6.43,-1.82,;7.94,-1.5,)| | ||
Structure |