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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50171332 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_303781 (CHEMBL830138) | ||
| Ki | 1.1±n/a nM | ||
| Citation |  Guo, Z; Tellew, JE; Gross, RS; Dyck, B; Grey, J; Haddach, M; Kiankarimi, M; Lanier, M; Li, BF; Luo, Z; McCarthy, JR; Moorjani, M; Saunders, J; Sullivan, R; Zhang, X; Zamani-Kord, S; Grigoriadis, DE; Crowe, PD; Chen, TK; Williams, JP Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists. J Med Chem48:5104-7 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50171332 | |||
| n/a | |||
| Name | BDBM50171332 | ||
| Synonyms: | 1-(2-Bromo-4-isopropyl-phenyl)-7-methyl-5-(1-propyl-butyl)-4,5-dihydro-1H,3H-1,2a,5,8-tetraaza-acenaphthylen-2-one | CHEMBL191090 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H33BrN4O | ||
| Mol. Mass. | 485.46 | ||
| SMILES | CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(cc1Br)C(C)C)c2=O |(-5.8,2.54,;-4.46,3.31,;-3.13,2.54,;-1.79,3.31,;-1.78,4.86,;-.44,5.63,;-.44,7.18,;-.44,2.52,;.9,3.29,;2.23,2.52,;2.22,.97,;.89,.2,;-.44,.97,;-1.78,.19,;-1.78,-1.36,;-3.27,-1.8,;.08,-2.35,;1.22,-1.32,;2.76,-1.46,;3.73,-2.67,;3.16,-4.1,;4.14,-5.31,;5.66,-5.06,;6.2,-3.63,;5.25,-2.44,;5.81,-1.01,;6.41,-6.39,;5.64,-7.72,;7.96,-6.41,;3.37,-.05,;4.89,.27,)| | ||
| Structure | 
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