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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Activin receptor type-1 | ||
| Ligand | BDBM451816 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2219788 (CHEMBL5133122) | ||
| IC50 | 3.6±n/a nM | ||
| Citation |  Witten, MR; Wu, L; Lai, CT; Kapilashrami, K; Pusey, M; Gallagher, K; Chen, Y; Yao, W Inhibition of ALK2 with bicyclic pyridyllactams. Bioorg Med Chem Lett55:0 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Activin receptor type-1 | |||
| Name: | Activin receptor type-1 | ||
| Synonyms: | 2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I | ||
| Type: | n/a | ||
| Mol. Mass.: | 57158.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 509 | ||
| Sequence: |
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| BDBM451816 | |||
| n/a | |||
| Name | BDBM451816 | ||
| Synonyms: | US10710980, Example 46 | US10947218, Example 46 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H33FN4O2 | ||
| Mol. Mass. | 440.5535 | ||
| SMILES | C[C@@H]1CCCN1Cc1ccc(cc1F)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@](C)(O)CC1 |r,wU:24.26,27.30,1.0,wD:27.31,(4.77,-2.71,;6.24,-3.19,;6.71,-4.65,;8.25,-4.65,;8.73,-3.19,;7.48,-2.28,;7.48,-.74,;6.15,.03,;4.81,-.74,;3.48,.03,;3.48,1.57,;4.81,2.34,;6.15,1.57,;7.48,2.34,;2.15,2.34,;2.15,3.88,;.81,4.65,;-.52,3.88,;-1.85,4.65,;-.52,2.34,;.81,1.57,;-1.85,1.57,;-1.85,.03,;-3.19,2.34,;-4.52,1.57,;-4.52,.03,;-5.85,-.74,;-7.19,.03,;-7.96,-1.3,;-8.73,.03,;-7.19,1.57,;-5.85,2.34,)| | ||
| Structure | 
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