| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Activin receptor type-1 |
|---|
| Ligand | BDBM50596223 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2219790 (CHEMBL5133124) |
|---|
| IC50 | 2.9±n/a nM |
|---|
| Citation |  Witten, MR; Wu, L; Lai, CT; Kapilashrami, K; Pusey, M; Gallagher, K; Chen, Y; Yao, W Inhibition of ALK2 with bicyclic pyridyllactams. Bioorg Med Chem Lett55:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Activin receptor type-1 |
|---|
| Name: | Activin receptor type-1 |
|---|
| Synonyms: | 2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 57158.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 509 |
|---|
| Sequence: | MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
|
|
|
|---|
| BDBM50596223 |
|---|
| n/a |
|---|
| Name | BDBM50596223 |
|---|
| Synonyms: | CHEMBL5200241 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H32N6O |
|---|
| Mol. Mass. | 408.5398 |
|---|
| SMILES | CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c2C(=O)N(CCc12)C1CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
