| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholine receptor subunit epsilon |
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| Ligand | BDBM50596365 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2220327 (CHEMBL5133661) |
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| IC50 | 2.3±n/a nM |
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| Citation |  Shi, Y; Zhang, H; Song, Q; Yu, G; Liu, Z; Zhong, F; Tan, Z; Liu, X; Deng, Y Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease. Eur J Med Chem230:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholine receptor subunit epsilon |
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| Name: | Acetylcholine receptor subunit epsilon |
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| Synonyms: | ACHE_HUMAN | ACHRE | Acetylcholine receptor protein epsilon chain | CHRNE | Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54686.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_431077 |
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| Residue: | 493 |
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| Sequence: | MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNL
ISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF
GVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF
AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKP
LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLS
VPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPP
EAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEV
RCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFN
RVPDLPYAPCIQP
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| BDBM50596365 |
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| n/a |
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| Name | BDBM50596365 |
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| Synonyms: | CHEMBL5179810 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H39N5O3 |
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| Mol. Mass. | 505.6517 |
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| SMILES | CCN(CCCCCCn1nc(ccc1=O)-c1cc(NC(C)=O)ccc1O)Cc1ccccc1N(C)C |
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| Structure | 
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