| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent phosphate transport protein 2B |
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| Ligand | BDBM50596515 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2220646 (CHEMBL5133980) |
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| IC50 | 36±n/a nM |
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| Citation |  Ushiki, Y; Kawabe, K; Yamamoto-Okada, K; Uneuchi, F; Asanuma, Y; Yamaguchi, C; Ohta, H; Shibata, T; Abe, T; Okumura-Kitajima, L; Kosai, Y; Endo, M; Otake, K; Munetomo, E; Takahashi, T; Kakinuma, H Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors. Bioorg Med Chem Lett59:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent phosphate transport protein 2B |
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| Name: | Sodium-dependent phosphate transport protein 2B |
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| Synonyms: | NPT2B_HUMAN | Na(+)-dependent phosphate cotransporter 2B | Na(+)/Pi cotransporter 2B | NaPi-2b | NaPi3b | SLC34A2 | Sodium-phosphate transport protein 2B | Sodium/phosphate cotransporter 2B | Solute carrier family 34 member 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 75771.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O95436 |
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| Residue: | 690 |
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| Sequence: | MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLI
DEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSS
AFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRA
AIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHY
LEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVK
IWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLP
DLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAI
LVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNA
LRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLI
PLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSL
KPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVK
APETFDNITISREAQGEVPASDSKTECTAL
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| BDBM50596515 |
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| n/a |
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| Name | BDBM50596515 |
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| Synonyms: | CHEMBL5204879 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H48ClN5O5S |
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| Mol. Mass. | 746.358 |
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| SMILES | CCC(CC)N(CCN(C)C(=O)CCC(O)=O)Cc1cccc(c1)C(=O)Nc1sc2CC(C)(C)CCc2c1C(=O)c1cnn(c1)-c1ccc(Cl)cc1 |
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| Structure | 
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