Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50173173 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_321225 (CHEMBL880234) |
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IC50 | 54±n/a nM |
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Citation | Graczyk, PP; Khan, A; Bhatia, GS; Palmer, V; Medland, D; Numata, H; Oinuma, H; Catchick, J; Dunne, A; Ellis, M; Smales, C; Whitfield, J; Neame, SJ; Shah, B; Wilton, D; Morgan, L; Patel, T; Chung, R; Desmond, H; Staddon, JM; Sato, N; Inoue, A The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold. Bioorg Med Chem Lett15:4666-70 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50173173 |
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n/a |
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Name | BDBM50173173 |
Synonyms: | CHEMBL383348 | {4-[(S)-2-(4-Fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-yl}-propyl-amine |
Type | Small organic molecule |
Emp. Form. | C28H30FN5O2 |
Mol. Mass. | 487.5685 |
SMILES | CCCNc1nccc(n1)-c1c(nc2CC[C@@H](COCc3ccc(OC)cc3)n12)-c1ccc(F)cc1 |
Structure |
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