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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-interacting serine/threonine-protein kinase 2 | ||
| Ligand | BDBM50597338 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2223237 (CHEMBL5136571) | ||
| IC50 | 1.6±n/a nM | ||
| Citation |  Yuan, X; Chen, Y; Tang, M; Wei, Y; Shi, M; Yang, Y; Zhou, Y; Yang, T; Liu, J; Liu, K; Deng, D; Zhang, C; Chen, L Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs). J Med Chem65:9312-9327 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Receptor-interacting serine/threonine-protein kinase 2 | |||
| Name: | Receptor-interacting serine/threonine-protein kinase 2 | ||
| Synonyms: | CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2 | ||
| Type: | Protein | ||
| Mol. Mass.: | 61201.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 540 | ||
| Sequence: |
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| BDBM50597338 | |||
| n/a | |||
| Name | BDBM50597338 | ||
| Synonyms: | CHEMBL5195615 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H20FN5 | ||
| Mol. Mass. | 325.3833 | ||
| SMILES | N[C@H]1CC[C@H](CC1)n1cc(-c2ccc(F)cc2)c2c(N)ncnc12 |r,wU:4.7,1.0,(2.52,-7.19,;2.12,-5.71,;.63,-5.31,;.23,-3.82,;1.32,-2.73,;2.81,-3.13,;3.21,-4.62,;.92,-1.24,;1.83,0,;.92,1.25,;1.32,2.74,;.23,3.82,;.63,5.31,;2.12,5.71,;2.52,7.19,;3.21,4.62,;2.82,3.14,;-.54,.77,;-1.87,1.54,;-1.87,3.08,;-3.21,.77,;-3.21,-.77,;-1.87,-1.54,;-.54,-.77,)| | ||
| Structure | 
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