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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-interacting serine/threonine-protein kinase 2 | ||
| Ligand | BDBM50597341 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2223237 (CHEMBL5136571) | ||
| IC50 | 0.800000±n/a nM | ||
| Citation |  Yuan, X; Chen, Y; Tang, M; Wei, Y; Shi, M; Yang, Y; Zhou, Y; Yang, T; Liu, J; Liu, K; Deng, D; Zhang, C; Chen, L Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs). J Med Chem65:9312-9327 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Receptor-interacting serine/threonine-protein kinase 2 | |||
| Name: | Receptor-interacting serine/threonine-protein kinase 2 | ||
| Synonyms: | CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2 | ||
| Type: | Protein | ||
| Mol. Mass.: | 61201.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 540 | ||
| Sequence: |
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| BDBM50597341 | |||
| n/a | |||
| Name | BDBM50597341 | ||
| Synonyms: | CHEMBL5187454 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21N5O2 | ||
| Mol. Mass. | 351.4023 | ||
| SMILES | N[C@H]1CC[C@H](CC1)n1cc(-c2ccc3OCOc3c2)c2c(N)ncnc12 |r,wU:4.7,1.0,(2.52,-7.5,;2.12,-6.01,;.63,-5.61,;.23,-4.12,;1.32,-3.03,;2.81,-3.43,;3.21,-4.92,;.92,-1.55,;1.83,-.3,;.92,.95,;1.32,2.43,;2.82,2.83,;3.21,4.32,;2.12,5.4,;2.2,6.94,;.76,7.5,;-.21,6.3,;.63,5.01,;.23,3.52,;-.54,.47,;-1.87,1.24,;-1.87,2.78,;-3.21,.47,;-3.21,-1.07,;-1.87,-1.84,;-.54,-1.07,)| | ||
| Structure | 
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