| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 4 |
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| Ligand | BDBM50174519 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321101 (CHEMBL882071) |
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| EC50 | >1000000±n/a nM |
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| Citation |  Conti, P; De Amici, M; Grazioso, G; Roda, G; Pinto, A; Hansen, KB; Nielsen, B; Madsen, U; Bräuner-Osborne, H; Egebjerg, J; Vestri, V; Pellegrini-Giampietro, DE; Sibille, P; Acher, FC; De Micheli, C Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids. J Med Chem48:6315-25 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 4 |
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| Name: | Metabotropic glutamate receptor 4 |
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| Synonyms: | GRM4_RAT | Gprc1d | Grm4 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 4 (mGlu4) | Mglur4 | mGlu4 | metabotropic glutamate 4 | metabotropic glutamate 4a |
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| Type: | Enzyme |
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| Mol. Mass.: | 101849.79 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P31423 |
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| Residue: | 912 |
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| Sequence: | MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQ
KSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIA
ATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALAT
KQTYVTYTNHAI
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| BDBM50174519 |
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| n/a |
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| Name | BDBM50174519 |
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| Synonyms: | (3aR,5R,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-3,5-dicarboxylic acid | CHEMBL198310 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H10N2O5 |
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| Mol. Mass. | 214.1754 |
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| SMILES | N[C@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O |c:5| |
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| Structure | 
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