Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174868

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

3±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174868

n/a

Name

BDBM50174868

Synonyms:

CHEMBL409589 | X3-Apc-DPhe-Arg-Trp-Z9-NH2

Type

Small organic molecule

Emp. Form.

C54H60N10O6

Mol. Mass.

945.1176

SMILES

NC(N)=NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(CC[C@@H](CC1)c1ccccc1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1C(N)=O |wU:7.7,25.29,11.19,22.36,wD:47.50,22.22,(15.73,-39.53,;14.39,-40.31,;13.06,-39.53,;14.39,-41.86,;13.06,-42.63,;13.06,-44.17,;11.72,-44.94,;11.72,-46.48,;10.38,-47.26,;9.04,-46.48,;9.04,-44.94,;7.71,-47.26,;7.71,-48.8,;9.04,-49.57,;9.03,-51.12,;10.37,-51.89,;11.71,-51.12,;11.7,-49.57,;10.37,-48.8,;6.38,-46.48,;5.03,-47.26,;5.03,-48.8,;3.7,-46.48,;5.03,-45.72,;5.04,-44.19,;3.71,-43.42,;2.38,-44.18,;2.37,-45.73,;3.72,-41.88,;5.06,-41.12,;5.06,-39.59,;3.73,-38.81,;2.4,-39.58,;2.4,-41.12,;2.36,-47.26,;1.02,-46.48,;1.02,-44.94,;-.31,-47.26,;-1.64,-46.49,;-1.64,-44.96,;-2.96,-44.19,;-4.3,-44.96,;-4.28,-46.5,;-2.95,-47.27,;13.06,-47.26,;13.06,-48.8,;14.39,-46.48,;15.73,-47.26,;15.73,-48.8,;17.07,-49.57,;18.41,-48.79,;19.51,-50.09,;18.75,-51.43,;19.23,-52.89,;18.19,-54.03,;16.68,-53.72,;16.21,-52.24,;17.24,-51.1,;17.07,-46.48,;17.07,-44.94,;18.41,-47.26,;19.74,-46.48,;20.81,-47.58,;22.3,-47.21,;22.71,-45.73,;21.63,-44.62,;20.15,-45.01,;19.07,-43.92,;19.48,-42.43,;17.58,-44.3,)|

Structure