Ki Summary

Reaction Details

Report a problem with these data

Target

Melanocortin receptor 4

Ligand

BDBM50174890

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

90±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174890

n/a

Name

BDBM50174890

Synonyms:

Bu-Apc-DPhe-Arg-2-Nal-Z4-NH2 | CHEMBL436296

Type

Small organic molecule

Emp. Form.

C48H61N9O6

Mol. Mass.

860.0546

SMILES

CCCC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)NCCC(N)=O |wU:21.22,32.34,9.12,6.5,wD:6.19,(-7.6,-9.56,;-6.26,-8.8,;-4.94,-9.57,;-3.6,-8.8,;-3.6,-7.26,;-2.27,-9.57,;-.91,-8.8,;.41,-8.04,;.42,-6.51,;-.91,-5.73,;-2.24,-6.5,;-2.25,-8.04,;-.9,-4.21,;.44,-3.44,;.44,-1.9,;-.89,-1.13,;-2.22,-1.9,;-2.22,-3.43,;.41,-9.57,;.41,-11.11,;1.75,-8.8,;3.09,-9.57,;3.09,-11.11,;4.42,-11.89,;4.41,-13.43,;5.74,-14.19,;7.09,-13.43,;7.08,-11.88,;5.75,-11.12,;4.42,-8.8,;4.42,-7.26,;5.76,-9.57,;7.09,-8.8,;7.09,-7.26,;8.43,-6.48,;8.43,-4.94,;9.77,-4.17,;9.77,-2.62,;11.1,-1.85,;8.43,-1.85,;8.43,-9.57,;8.43,-11.11,;9.77,-8.8,;11.1,-9.57,;11.1,-11.11,;12.44,-11.89,;13.77,-11.12,;15.1,-11.89,;15.11,-13.44,;16.44,-14.21,;16.44,-15.75,;15.09,-16.53,;13.76,-15.75,;13.77,-14.2,;12.44,-13.44,;12.44,-8.8,;12.44,-7.26,;13.78,-9.57,;15.11,-8.8,;16.44,-9.56,;17.76,-8.79,;19.09,-9.55,;17.76,-7.25,)|

Structure