| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor |
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| Ligand | BDBM50175413 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326622 (CHEMBL863381) |
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| IC50 | 8.5±n/a nM |
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| Citation |  Chesworth, R; Wessel, MD; Heyden, L; Mangano, FM; Zawistoski, M; Gegnas, L; Galluzzo, D; Lefker, B; Cameron, KO; Tickner, J; Lu, B; Castleberry, TA; Petersen, DN; Brault, A; Perry, P; Ng, O; Owen, TA; Pan, L; Ke, HZ; Brown, TA; Thompson, DD; DaSilva-Jardine, P Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett15:5562-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor |
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| Name: | Estrogen receptor |
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| Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
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| Type: | Protein |
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| Mol. Mass.: | 66230.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372 |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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| BDBM50175413 |
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| n/a |
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| Name | BDBM50175413 |
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| Synonyms: | 4-(4-phenyl-5-(trifluoromethyl)isoxazol-3-yl)phenol | CHEMBL200021 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10F3NO2 |
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| Mol. Mass. | 305.2513 |
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| SMILES | Oc1ccc(cc1)-c1noc(c1-c1ccccc1)C(F)(F)F |
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| Structure | 
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