| Reaction Details |
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 | Report a problem with these data |
| Target | S-adenosylmethionine synthase isoform type-2 |
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| Ligand | BDBM50575978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2227553 (CHEMBL5141066) |
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| IC50 | 8.0±n/a nM |
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| Citation |  Li, C; Gui, G; Zhang, L; Qin, A; Zhou, C; Zha, X Overview of Methionine Adenosyltransferase 2A (MAT2A) as an Anticancer Target: Structure, Function, and Inhibitors. J Med Chem65:9531-9547 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| S-adenosylmethionine synthase isoform type-2 |
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| Name: | S-adenosylmethionine synthase isoform type-2 |
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| Synonyms: | AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II |
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| Type: | Protein |
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| Mol. Mass.: | 43659.65 |
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| Organism: | Human |
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| Description: | P31153 |
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| Residue: | 395 |
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| Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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| BDBM50575978 |
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| n/a |
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| Name | BDBM50575978 |
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| Synonyms: | CHEMBL4860456 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13N3O |
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| Mol. Mass. | 239.2725 |
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| SMILES | Cc1nn2c([nH]c(C)cc2=O)c1-c1ccccc1 |
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| Structure | 
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