Reaction Details | |||
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Target | Mitogen-activated protein kinase 14 | ||
Ligand | BDBM50175749 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_328206 (CHEMBL863945) | ||
IC50 | 0.77±n/a nM | ||
Citation | Bao, J; Hunt, JA; Miao, S; Rupprecht, KM; Stelmach, JE; Liu, L; Ruzek, RD; Sinclair, PJ; Pivnichny, JV; Hop, CE; Kumar, S; Zaller, DM; Shoop, WL; O'neill, EA; O'keefe, SJ; Thompson, CM; Cubbon, RM; Wang, R; Zhang, WX; Thompson, JE; Doherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett16:64-8 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase 14 | |||
Name: | Mitogen-activated protein kinase 14 | ||
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 41286.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16539 | ||
Residue: | 360 | ||
Sequence: |
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BDBM50175749 | |||
n/a | |||
Name | BDBM50175749 | ||
Synonyms: | 7-(1-tert-butylpiperidin-4-yloxy)-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)quinolin-2(1H)-one | CHEMBL199435 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H28Cl2F2N2O2 | ||
Mol. Mass. | 557.458 | ||
SMILES | CC(C)(C)N1CCC(CC1)Oc1cc(-c2ccc(F)cc2F)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(31.06,-19.78,;29.74,-19.02,;28.97,-20.35,;30.51,-17.69,;28.4,-18.25,;27.07,-19.02,;25.74,-18.25,;25.73,-16.71,;27.06,-15.93,;28.4,-16.71,;24.39,-15.94,;23.06,-16.72,;23.07,-18.27,;21.73,-19.04,;21.73,-20.57,;20.4,-21.34,;20.4,-22.88,;21.73,-23.65,;21.73,-25.19,;23.07,-22.87,;23.06,-21.34,;24.4,-20.57,;20.4,-18.27,;19.07,-19.05,;17.73,-18.27,;17.73,-16.73,;16.4,-15.95,;19.07,-15.96,;19.07,-14.42,;17.74,-13.66,;16.41,-14.43,;17.74,-12.12,;19.07,-11.35,;20.41,-12.12,;20.41,-13.66,;21.74,-14.43,;20.4,-16.72,;21.73,-15.95,)| | ||
Structure |