Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50176009 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_327352 (CHEMBL863439) |
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IC50 | 47±n/a nM |
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Citation | Revesz, L; Blum, E; Di Padova, FE; Buhl, T; Feifel, R; Gram, H; Hiestand, P; Manning, U; Neumann, U; Rucklin, G Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity. Bioorg Med Chem Lett16:262-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha |
Type: | Enzyme |
Mol. Mass.: | 41281.22 |
Organism: | Mus musculus (mouse) |
Description: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography. |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50176009 |
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n/a |
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Name | BDBM50176009 |
Synonyms: | 4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-4-methoxyphenyl)-2-methylbutan-2-ol | CHEMBL199595 |
Type | Small organic molecule |
Emp. Form. | C23H23F2N5O2 |
Mol. Mass. | 439.4578 |
SMILES | COc1ccc(CCC(C)(C)O)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12 |
Structure |
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