| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide N-methyltransferase |
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| Ligand | BDBM50598881 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2228242 (CHEMBL5141755) |
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| IC50 | 1.1±n/a nM |
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| Citation |  Yoshida, S; Uehara, S; Kondo, N; Takahashi, Y; Yamamoto, S; Kameda, A; Kawagoe, S; Inoue, N; Yamada, M; Yoshimura, N; Tachibana, Y Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides. J Med Chem65:10655-10673 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide N-methyltransferase |
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| Name: | Nicotinamide N-methyltransferase |
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| Synonyms: | NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT) |
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| Type: | Protein |
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| Mol. Mass.: | 29571.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 264 |
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| Sequence: | MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
SYSSTMANNEGLFSLVARKLSRPL
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| BDBM50598881 |
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| n/a |
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| Name | BDBM50598881 |
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| Synonyms: | CHEMBL5194905 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H34ClN7O |
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| Mol. Mass. | 592.133 |
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| SMILES | Cc1cc(CN)n(n1)[C@H]1C[C@@H](N(C1)C(=O)c1cnc2[nH]c(C)cc2c1)c1cc2cc(C)ccc2n1Cc1ccc(Cl)cc1 |r| |
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| Structure | 
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