Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM50598916 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2228481 (CHEMBL5141994) |
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IC50 | 2.4±n/a nM |
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Citation | Cisar, JS; Pietsch, C; DeRatt, LG; Jacoby, E; Kazmi, F; Keohane, C; Legenski, K; Matico, R; Shaffer, P; Simonnet, Y; Tanner, A; Wang, CY; Wang, W; Attar, R; Edwards, JP; Kuduk, SD -Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia. J Med Chem65:11241-11256 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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BDBM50598916 |
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n/a |
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Name | BDBM50598916 |
Synonyms: | CHEMBL5205042 |
Type | Small organic molecule |
Emp. Form. | C21H20F6N6O4 |
Mol. Mass. | 534.4117 |
SMILES | CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(C)ccnc2C(F)F)c1=O |r| |
Structure |
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