| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Pro-cathepsin H |
|---|
| Ligand | BDBM50148298 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_334150 (CHEMBL868301) |
|---|
| IC50 | 18±n/a nM |
|---|
| Citation |  Adkison, KK; Barrett, DG; Deaton, DN; Gampe, RT; Hassell, AM; Long, ST; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg Med Chem Lett16:978-83 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Pro-cathepsin H |
|---|
| Name: | Pro-cathepsin H |
|---|
| Synonyms: | CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 37402.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1459870 |
|---|
| Residue: | 335 |
|---|
| Sequence: | MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG
CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV
EAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK
NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
|
|
|
|---|
| BDBM50148298 |
|---|
| n/a |
|---|
| Name | BDBM50148298 |
|---|
| Synonyms: | ((S)-1-Formyl-pentyl)-carbamic acid (R)-1-benzyl-2-methyl-propyl ester | (1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE | (R)-3-methyl-1-phenylbutan-2-yl (S)-1-oxohexan-2-ylcarbamate | CHEMBL113948 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H27NO3 |
|---|
| Mol. Mass. | 305.4119 |
|---|
| SMILES | CCCC[C@H](NC(=O)O[C@H](Cc1ccccc1)C(C)C)C=O |
|---|
| Structure | 
|
|---|
Search and Browse
