| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocyte-stimulating hormone receptor |
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| Ligand | BDBM50177564 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_349445 (CHEMBL865697) |
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| Ki | 7000±n/a nM |
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| Citation |  Shi, Q; Ornstein, PL; Briner, K; Richardson, TI; Arnold, MB; Backer, RT; Buckmaster, JL; Canada, EJ; Doecke, CW; Hertel, LW; Honigschmidt, N; Hsiung, HM; Husain, S; Kuklish, SL; Martinelli, MJ; Mullaney, JT; O'Brien, TP; Reinhard, MR; Rothhaar, R; Shah, J; Wu, Z; Xie, C; Zgombick, JM; Fisher, MJ Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor. Bioorg Med Chem Lett16:2341-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocyte-stimulating hormone receptor |
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| Name: | Melanocyte-stimulating hormone receptor |
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| Synonyms: | MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 34717.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q01726 |
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| Residue: | 317 |
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| Sequence: | MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
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| BDBM50177564 |
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| n/a |
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| Name | BDBM50177564 |
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| Synonyms: | CHEMBL380540 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(diethylamino)-1-(2-fluorophenyl)ethyl)piperazin-1-yl)-1-oxopropan-2-yl)-1,1-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C37H47ClFN5O2 |
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| Mol. Mass. | 648.253 |
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| SMILES | CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1Cc2ccccc2C(C)(C)N1)c1ccccc1F |
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| Structure | 
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