| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 3A |
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| Ligand | BDBM50000483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2232054 (CHEMBL5145826) |
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| Ki | 4.0±n/a nM |
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| Citation |  Juza, R; Vojtechova, I; Stefkova-Mazochova, K; Dehaen, W; Petrasek, T; Prchal, L; Kobrlova, T; Janousek, J; Vlcek, P; Mezeiova, E; Svozil, D; Karasova, JZ; Pejchal, J; Stark, H; Satala, G; Bojarski, AJ; Kubacka, M; Mogilski, S; Randakova, A; Musilek, K; Soukup, O; Korabecny, J Novel D Eur J Med Chem232:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 3A |
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| Name: | 5-hydroxytryptamine receptor 3A |
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| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_CAVPO | 5HT3R | HTR3 | HTR3A | Serotonin 3a (5-HT3a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 55657.07 |
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| Organism: | GUINEA PIG |
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| Description: | 5-HT3 HTR3A GUINEA PIG::O70212 |
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| Residue: | 490 |
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| Sequence: | MVLWLQLALLALLLPTSLAQGEVRGKGTAQAHNSTRPALQRLSDHLLADYRKSVRPVRDW
RKPTTVSIDAIVYAILSVDEKNQVLTTYIWYRQFWTDEFLQWNPEDFDNITKLSIPTDSI
WVPDILINEFVDVGKSPNIPYVYVRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRLPEKVKSDKSVFMNQGEWELLGVLTEFLEFSDRESRGSFAEMKF
YVVIRRRPLFYAVTLLLPSIFLMIVDIVGFYLPPDSGERVSFKITLLLGYSVFLIIVSDT
LPATAIGTPLISVYFVVCMALLVISLAETILIVRLVHKQDLQQPVPLWLRHLVLERIAGL
LCLGEQLTSHRGPATLQATKTDDFSGSTLLPAMGNHCGPLGGPQDLEKTSRGRGSPPPPP
REASLAMCGLLQELASIRHFLEKREETREVARDWLRVGSVLDKLLFRVYLLAVLAYSITL
VTLWSVWHYA
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| BDBM50000483 |
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| n/a |
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| Name | BDBM50000483 |
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| Synonyms: | (BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide | (granisetron)1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide | 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide | 1-Methyl-1H-indazole-3-carboxylic acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide | 1-Methyl-1H-indazole-3-carboxylic acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide(BRL 43694) | 1-Methyl-1H-indazole-3-carboxylic acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide(Granisetron) | 1-methyl-N-((1S,5R)-9-methyl-9-aza-bicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide | 2-(9-Methyl-3,9-diaza-bicyclo[3.3.1]non-3-yl)-1-(1-methyl-1H-indol-3-yl)-ethanone(Granisetron) | BRL 43694 | BRL-43694 | CHEMBL519643 | GRANISETRON | LY-278584 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24N4O |
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| Mol. Mass. | 312.4094 |
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| SMILES | CN1C2CCCC1CC(C2)NC(=O)c1nn(C)c2ccccc12 |THB:10:8:1:3.5.4| |
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| Structure | 
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