| Reaction Details |
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 | Report a problem with these data |
| Target | DNA helicase IV |
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| Ligand | BDBM50177710 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_334855 (CHEMBL871172) |
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| IC50 | 1400±n/a nM |
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| Citation |  Dubaele, S; Jahnke, W; Schoepfer, J; Fuchs, J; Chène, P Inhibition of DNA helicases with DNA-competitive inhibitors. Bioorg Med Chem Lett16:923-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA helicase IV |
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| Name: | DNA helicase IV |
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| Synonyms: | HELD_ECOLI | Helicase IV | helD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77988.86 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | ChEMBL_334855 |
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| Residue: | 684 |
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| Sequence: | MELKATTLGKRLAQHPYDRAVILNAGIKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFV
LPDEKVVRLHGTEWGETQRFYHHLDAHWRRWSGEMSEIASGVLRQQLDLIATRTGENKWL
TREQTSGVQQQIRQALSALPLPVNRLEEFDNCREAWRKCQAWLKDIESARLQHNQAYTEA
MLTEYADFFRQVESSPLNPAQARAVVNGEHSLLVLAGAGSGKTSVLVARAGWLLARGEAS
PEQILLLAFGRKAAEEMDERIRERLHTEDITARTFHALALHIIQQGSKKVPIVSKLENDT
AARHELFIAEWRKQCSEKKAQAKGWRQWLTEEMQWSVPEGNFWDDEKLQRRLASRLDRWV
SLMRMHGGAQAEMIASAPEEIRDLFSKRIKLMAPLLKAWKGALKAENAVDFSGLIHQAIV
ILEKGRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGAQM
SLTTAFHENFGEGERCDLDTTYRFNSRIGEVANRFIQQNPGQLKKPLNSLTNGDKKAVTL
LDESQLDALLDKLSGYAKPEERILILARYHHMRPASLEKAATRWPKLQIDFMTIHASKGQ
QADYVIIVGLQEGSDGFPAAARESIMEEALLPPVEDFPDAEERRLMYVALTRARHRVWAL
FNKENPSPFVEILKNLDVPVARKP
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| BDBM50177710 |
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| n/a |
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| Name | BDBM50177710 |
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| Synonyms: | (3-acetylamino-5-oxo-5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-7-yl)-acetic acid | CHEMBL201975 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15NO4S |
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| Mol. Mass. | 341.381 |
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| SMILES | CC(=O)Nc1ccc2CSc3ccc(CC(O)=O)cc3C(=O)c2c1 |
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| Structure | 
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