BindingDB PrimarySearch

Found 143 hits with Last Name = 'fuchs' and Initial = 'j'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50505841 (CHEMBL4532034 \| US11174245, # I-018) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Orphan methyltransferase M.SssI (Spiroplasma monobiae strain MQ-1)	BDBM50059989 ((1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-phenyl)-he...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of Spiroplasma sp. MQ-1 M.SssI				Bioorg Med Chem Lett 19: 706-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.041 BindingDB Entry DOI: 10.7270/Q2PV6M8R
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Orphan methyltransferase M.SssI (Spiroplasma monobiae strain MQ-1)	BDBM50067040 (((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of Spiroplasma sp. MQ-1 M.SssI				Bioorg Med Chem Lett 19: 706-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.041 BindingDB Entry DOI: 10.7270/Q2PV6M8R
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Orphan methyltransferase M.SssI (Spiroplasma monobiae strain MQ-1)	BDBM50163744 ((1E,4Z,6E)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of Spiroplasma sp. MQ-1 M.SssI				Bioorg Med Chem Lett 19: 706-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.041 BindingDB Entry DOI: 10.7270/Q2PV6M8R
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Transcription factor p65 (Homo sapiens (Human))	BDBM50196926 (CHEMBL438139 \| Rocaglamide \| US10085988, Compound ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELI...				J Nat Prod 74: 1117-25 (2011) Article DOI: 10.1021/np200051j BindingDB Entry DOI: 10.7270/Q20C4W31
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Mus musculus)	BDBM50029668 (AZD-9291 \| Osimertinib \| US10085983, Compound AZD-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436 (Homo sapiens (Human))	BDBM50593519 (CHEMBL5204252) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jnatprod.2c00036 BindingDB Entry DOI: 10.7270/Q2J10752
TBA					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM188497 (2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Integrase (Human immunodeficiency virus 1)	BDBM188497 (2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of biotinylated-TAR-RNA binding to HIV1 His6-tagged integrase expressed in Escherichia coli BL21(DE3) preincubated for 2 hrs followed by R...				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Integrase (Human immunodeficiency virus 1)	BDBM188497 (2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75-dependant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Integrase (Human immunodeficiency virus 1)	BDBM188497 (2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75 binding to HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM188497 (2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...				J Biol Chem 288: 15813-20 (2013) Article DOI: 10.1074/jbc.M112.443390 BindingDB Entry DOI: 10.7270/Q23R0RP6
The Ohio State University					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM188497 (2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...				J Biol Chem 288: 15813-20 (2013) Article DOI: 10.1074/jbc.M112.443390 BindingDB Entry DOI: 10.7270/Q23R0RP6
The Ohio State University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Mus musculus)	BDBM50505838 (CHEMBL4537790) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Integrase (Human immunodeficiency virus 1)	BDBM50508823 (CHEMBL4544303) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of biotinylated-TAR-RNA binding to HIV1 His6-tagged integrase expressed in Escherichia coli BL21(DE3) preincubated for 2 hrs followed by R...				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50505836 (CHEMBL4434788 \| US11174245, # I-064) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	267	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Mus musculus)	BDBM50505845 (CHEMBL4566193) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50505843 (CHEMBL4449589 \| US11174245, # I-235) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	353	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM50011132 (ALLINI-1 \| CHEMBL3259891) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...				J Biol Chem 288: 15813-20 (2013) Article DOI: 10.1074/jbc.M112.443390 BindingDB Entry DOI: 10.7270/Q23R0RP6
The Ohio State University					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50508823 (CHEMBL4544303) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50505839 (CHEMBL4525935 \| US11174245, # I-001) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	519	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50513777 (CHEMBL4534212) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of Papaya papain using Z-FR-MCA as substrate by spectrofluorimetric method				J Nat Prod 82: 657-679 (2019) Article DOI: 10.1021/acs.jnatprod.9b00018 BindingDB Entry DOI: 10.7270/Q29W0JTR
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Mus musculus)	BDBM50505841 (CHEMBL4532034 \| US11174245, # I-018) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50508831 (CHEMBL4450048) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50508826 (CHEMBL4476045) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Gag-Pol polyprotein [A1275T] (Human immunodeficiency virus 1 (Virus))	BDBM188497 (2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...				J Biol Chem 288: 15813-20 (2013) Article DOI: 10.1074/jbc.M112.443390 BindingDB Entry DOI: 10.7270/Q23R0RP6
The Ohio State University					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50535069 (CHEMBL4448648) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase A128T mutant expressed in Escherichia coli BL21(DE3) cells assessed as red...				Bioorg Med Chem Lett 26: 4748-4752 (2016) Article DOI: 10.1016/j.bmcl.2016.08.037 BindingDB Entry DOI: 10.7270/Q2R214VC
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM50011132 (ALLINI-1 \| CHEMBL3259891) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...				J Biol Chem 288: 15813-20 (2013) Article DOI: 10.1074/jbc.M112.443390 BindingDB Entry DOI: 10.7270/Q23R0RP6
The Ohio State University					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50508833 (CHEMBL4557062) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Mus musculus)	BDBM50505846 (CHEMBL4562138) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50508829 (CHEMBL4572060) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bangalore University Curated by ChEMBL					Assay Description Inhibition of COX2 (unknown origin)				Bioorg Med Chem Lett 25: 2931-6 (2015) Article DOI: 10.1016/j.bmcl.2015.05.047 BindingDB Entry DOI: 10.7270/Q2D220D5
Bangalore University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Integrase (Human immunodeficiency virus 1)	BDBM50508825 (CHEMBL4527313) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50011132 (ALLINI-1 \| CHEMBL3259891) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...				Bioorg Med Chem Lett 26: 4748-4752 (2016) Article DOI: 10.1016/j.bmcl.2016.08.037 BindingDB Entry DOI: 10.7270/Q2R214VC
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (Mus musculus)	BDBM50505842 (CHEMBL4519157) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
DNA helicase IV (Escherichia coli (strain K12))	BDBM50177710 ((3-acetylamino-5-oxo-5,11-dihydro-10-thia-dibenzo[...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of ATPase activity of Helicase4 from Escherichia coli in presence of ATP (5x Km(ATP)) and dT25 (5x KDNA)				Bioorg Med Chem Lett 16: 923-7 (2006) Article DOI: 10.1016/j.bmcl.2005.10.110 BindingDB Entry DOI: 10.7270/Q2MS3SB8
					More data for this Ligand-Target Pair
Trypsin (Homo sapiens (Human))	BDBM50513779 (CHEMBL4441556) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of trypsin (unknown origin) using Z-FR-MCA as substrate by spectrofluorimetric method				J Nat Prod 82: 657-679 (2019) Article DOI: 10.1021/acs.jnatprod.9b00018 BindingDB Entry DOI: 10.7270/Q29W0JTR
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50106343 (CHEMBL3596280) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bangalore University Curated by ChEMBL					Assay Description Inhibition of COX2 (unknown origin)				Bioorg Med Chem Lett 25: 2931-6 (2015) Article DOI: 10.1016/j.bmcl.2015.05.047 BindingDB Entry DOI: 10.7270/Q2D220D5
Bangalore University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50106341 (CHEMBL3596282) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bangalore University Curated by ChEMBL					Assay Description Inhibition of COX2 (unknown origin)				Bioorg Med Chem Lett 25: 2931-6 (2015) Article DOI: 10.1016/j.bmcl.2015.05.047 BindingDB Entry DOI: 10.7270/Q2D220D5
Bangalore University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50505837 (CHEMBL4591327) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Mus musculus)	BDBM50505840 (CHEMBL4550104) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50106342 (CHEMBL3596281) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bangalore University Curated by ChEMBL					Assay Description Inhibition of COX2 (unknown origin)				Bioorg Med Chem Lett 25: 2931-6 (2015) Article DOI: 10.1016/j.bmcl.2015.05.047 BindingDB Entry DOI: 10.7270/Q2D220D5
Bangalore University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50505844 (CHEMBL4444231) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Transcription factor p65 (Homo sapiens (Human))	BDBM50346334 (1,3,7-trihydroxy-2,4-diisoprenylxanthone \| CHEMBL1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELI...				J Nat Prod 74: 1117-25 (2011) Article DOI: 10.1021/np200051j BindingDB Entry DOI: 10.7270/Q20C4W31
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
DNA helicase IV (Escherichia coli (strain K12))	BDBM50177713 (2-(5-oxo-5,11-dihydro-10-thia-dibenzo[a,d]cyclohep...) Show SMILES CC(C(O)=O)c1ccc2SCc3ccccc3C(=O)c2c1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of ATPase activity of Helicase4 from Escherichia coli in presence of ATP (5x Km(ATP)) and dT25 (5x KDNA)				Bioorg Med Chem Lett 16: 923-7 (2006) Article DOI: 10.1016/j.bmcl.2005.10.110 BindingDB Entry DOI: 10.7270/Q2MS3SB8
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50535069 (CHEMBL4448648) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as reduction in LED...				Bioorg Med Chem Lett 26: 4748-4752 (2016) Article DOI: 10.1016/j.bmcl.2016.08.037 BindingDB Entry DOI: 10.7270/Q2R214VC
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50508835 (CHEMBL4526711) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assay				ACS Med Chem Lett 10: 215-220 (2019) Article DOI: 10.1021/acsmedchemlett.8b00633 BindingDB Entry DOI: 10.7270/Q24171C6
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Mus musculus)	BDBM50505843 (CHEMBL4449589 \| US11174245, # I-235) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169 BindingDB Entry DOI: 10.7270/Q2XD14ZQ
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					More data for this Ligand-Target Pair
Trypsin (Homo sapiens (Human))	BDBM241952 (Fukugetin) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of trypsin (unknown origin) using Z-FR-MCA as substrate by spectrofluorimetric method				J Nat Prod 82: 657-679 (2019) Article DOI: 10.1021/acs.jnatprod.9b00018 BindingDB Entry DOI: 10.7270/Q29W0JTR
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50106333 (CHEMBL3596289) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bangalore University Curated by ChEMBL					Assay Description Inhibition of COX2 (unknown origin)				Bioorg Med Chem Lett 25: 2931-6 (2015) Article DOI: 10.1016/j.bmcl.2015.05.047 BindingDB Entry DOI: 10.7270/Q2D220D5
Bangalore University Curated by ChEMBL					More data for this Ligand-Target Pair

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