| Reaction Details |
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 | Report a problem with these data |
| Target | Polyprenyl synthetase family protein |
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| Ligand | BDBM50180153 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_330072 (CHEMBL858875) |
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| IC50 | 12280±n/a nM |
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| Citation |  Hudock, MP; Sanz-Rodríguez, CE; Song, Y; Chan, JM; Zhang, Y; Odeh, S; Kosztowski, T; Leon-Rossell, A; Concepción, JL; Yardley, V; Croft, SL; Urbina, JA; Oldfield, E Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. J Med Chem49:215-23 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyprenyl synthetase family protein |
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| Name: | Polyprenyl synthetase family protein |
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| Synonyms: | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41078.35 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_330072 |
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| Residue: | 362 |
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| Sequence: | MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAE
AMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVT
TQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKL
DANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAM
VMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGST
DPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKR
QK
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| BDBM50180153 |
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| n/a |
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| Name | BDBM50180153 |
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| Synonyms: | 1-hydroxy-2-[3-(2,4-difluoro-5-methylphenyl)phenyl]ethylidene-1,1-biphosphonic acid | CHEMBL200107 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16F2O7P2 |
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| Mol. Mass. | 408.2277 |
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| SMILES | Cc1cc(c(F)cc1F)-c1cccc(CC(O)(P(O)(O)=O)P(O)(O)=O)c1 |
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| Structure | 
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