Reaction Details |
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Target | Serine/threonine-protein kinase Chk2 |
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Ligand | BDBM50601440 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2236952 (CHEMBL5150848) |
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IC50 | 5.1±n/a nM |
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Citation | Wang, Z; Cai, J; Cheng, J; Yang, W; Zhu, Y; Li, H; Lu, T; Chen, Y; Lu, S FLT3 Inhibitors in Acute Myeloid Leukemia: Challenges and Recent Developments in Overcoming Resistance. J Med Chem64:2878-2900 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk2 |
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Name: | Serine/threonine-protein kinase Chk2 |
Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
Type: | Protein |
Mol. Mass.: | 60908.59 |
Organism: | Homo sapiens (Human) |
Description: | O96017 |
Residue: | 543 |
Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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BDBM50601440 |
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n/a |
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Name | BDBM50601440 |
Synonyms: | CHEMBL5176837 |
Type | Small organic molecule |
Emp. Form. | C21H23N7O |
Mol. Mass. | 389.4536 |
SMILES | COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 |
Structure |
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