Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50181641 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_330651 (CHEMBL867029) |
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IC50 | 118±n/a nM |
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Citation | Tedesco, R; Shaw, AN; Bambal, R; Chai, D; Concha, NO; Darcy, MG; Dhanak, D; Fitch, DM; Gates, A; Gerhardt, WG; Halegoua, DL; Han, C; Hofmann, GA; Johnston, VK; Kaura, AC; Liu, N; Keenan, RM; Lin-Goerke, J; Sarisky, RT; Wiggall, KJ; Zimmerman, MN; Duffy, KJ 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem49:971-83 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50181641 |
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n/a |
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Name | BDBM50181641 |
Synonyms: | 1-butyn-3-yl-3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1Hquinolin-2-one | CHEMBL202271 |
Type | Small organic molecule |
Emp. Form. | C20H15N3O4S |
Mol. Mass. | 393.416 |
SMILES | Oc1c(C2=Nc3ccccc3S(=O)(=O)N2)c(=O)n(CCC#C)c2ccccc12 |t:3| |
Structure |
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