| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase beta |
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| Ligand | BDBM50181559 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_330659 (CHEMBL867037) |
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| IC50 | >50000±n/a nM |
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| Citation |  Tedesco, R; Shaw, AN; Bambal, R; Chai, D; Concha, NO; Darcy, MG; Dhanak, D; Fitch, DM; Gates, A; Gerhardt, WG; Halegoua, DL; Han, C; Hofmann, GA; Johnston, VK; Kaura, AC; Liu, N; Keenan, RM; Lin-Goerke, J; Sarisky, RT; Wiggall, KJ; Zimmerman, MN; Duffy, KJ 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem49:971-83 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase beta |
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| Name: | DNA polymerase beta |
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| Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
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| Type: | Protein |
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| Mol. Mass.: | 38188.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 335 |
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| Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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| BDBM50181559 |
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| n/a |
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| Name | BDBM50181559 |
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| Synonyms: | 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE | 1-(2-Cyclopropyl-ethyl)-3-(1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-3-yl)-6-fluoro-4-hydroxy-1H-quinolin-2-one | 1-(2-cyclopropylethyl)-3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]-thiadiazin-3-yl) -6-fluoro-4-hydroxy-1-quinolin-2-one | CHEMBL372357 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18FN3O4S |
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| Mol. Mass. | 427.449 |
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| SMILES | Oc1c(C2=Nc3ccccc3S(=O)(=O)N2)c(=O)n(CCC2CC2)c2ccc(F)cc12 |t:3| |
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| Structure | 
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