| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor erythroid 2-related factor 2 |
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| Ligand | BDBM50601805 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2238232 (CHEMBL5152128) |
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| EC50 | 3500±n/a nM |
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| Citation |  Norton, D; Bonnette, WG; Callahan, JF; Carr, MG; Griffiths-Jones, CM; Heightman, TD; Kerns, JK; Nie, H; Rich, SJ; Richardson, C; Rumsey, W; Sanchez, Y; Verdonk, ML; Willems, HMG; Wixted, WE; Wolfe, L; Woolford, AJ; Wu, Z; Davies, TG Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction. J Med Chem64:15949-15972 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor erythroid 2-related factor 2 |
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| Name: | Nuclear factor erythroid 2-related factor 2 |
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| Synonyms: | HEBP1 | Kelch-like ECH-associated protein 1 | NF-E2-related factor 2 | NF2L2_HUMAN | NFE2-related factor 2 | NFE2L2 | NRF2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67786.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107924 |
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| Residue: | 605 |
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| Sequence: | MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
DVKKN
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| BDBM50601805 |
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| n/a |
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| Name | BDBM50601805 |
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| Synonyms: | CHEMBL5208399 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30FN3O3 |
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| Mol. Mass. | 475.5545 |
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| SMILES | CCC[C@H]1CCCCN1C(=O)c1cccc(c1F)-c1cccc(c1)-n1ncc(C(O)=O)c1C1CC1 |r| |
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| Structure | 
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