| Reaction Details |
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 | Report a problem with these data |
| Target | Thioredoxin reductase |
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| Ligand | BDBM50182130 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_347983 (CHEMBL869602) |
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| IC50 | 10000±n/a nM |
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| Citation |  Andricopulo, AD; Akoachere, MB; Krogh, R; Nickel, C; McLeish, MJ; Kenyon, GL; Arscott, LD; Williams, CH; Davioud-Charvet, E; Becker, K Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. Bioorg Med Chem Lett16:2283-92 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thioredoxin reductase |
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| Name: | Thioredoxin reductase |
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| Synonyms: | TRXR | TRXR_PLAF7 | Thioredoxin reductase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68716.44 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_347983 |
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| Residue: | 617 |
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| Sequence: | MNNVISFIGNSSNKYFQINQLHFIRIINKNIHSKNNLINSNSSYNVFYNKYFIKNTFQNK
NKLSSIYSKLNFSIKNMCKDKNEKKNYEHVNANEKNGYLASEKNELTKNKVEEHTYDYDY
VVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKLMHYAGH
MGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYINGLAKLK
DKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDDIFSLKKDPGK
TLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYMEEQGVMFKNGIL
PKKLTKMDDKILVEFSDKTSELYDTVLYAIGRKGDIDGLNLESLNMNVNKSNNKIIADHL
SCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIMDYSYIPTSIYTPIEYG
ACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKDEYDLDVSSTCLAKLVC
LKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGIHPTDAESFMNLFVTIS
SGLSYAAKGGCGGGKCG
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| BDBM50182130 |
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| n/a |
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| Name | BDBM50182130 |
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| Synonyms: | 4,6-dinitrobenzo[c][1,2,5]thiadiazole | CHEMBL206140 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H2N4O4S |
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| Mol. Mass. | 226.169 |
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| SMILES | [O-][N+](=O)c1cc([N+]([O-])=O)c2nsnc2c1 |
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| Structure | 
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