| Reaction Details |
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 | Report a problem with these data |
| Target | Malonyl-CoA decarboxylase, mitochondrial |
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| Ligand | BDBM50183296 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_336476 (CHEMBL859660) |
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| IC50 | 14±n/a nM |
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| Citation |  Cheng, JF; Chen, M; Wallace, D; Tith, S; Haramura, M; Liu, B; Mak, CC; Arrhenius, T; Reily, S; Brown, S; Thorn, V; Harmon, C; Barr, R; Dyck, JR; Lopaschuk, GD; Nadzan, AM Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors. J Med Chem49:1517-25 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Malonyl-CoA decarboxylase, mitochondrial |
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| Name: | Malonyl-CoA decarboxylase, mitochondrial |
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| Synonyms: | DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55018.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_665404 |
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| Residue: | 493 |
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| Sequence: | MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKT
PAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAA
VLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNG
VLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFF
SHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQG
VELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSEC
KEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVA
NFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQV
LSLVAQFQKNSKL
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| BDBM50183296 |
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| n/a |
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| Name | BDBM50183296 |
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| Synonyms: | 5-{(morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino}pentanoic acid | CHEMBL206756 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22F6N2O5 |
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| Mol. Mass. | 472.3788 |
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| SMILES | OC(=O)CCCCN(C(=O)N1CCOCC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F |
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| Structure | 
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