| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50153250 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_337085 (CHEMBL854142) |
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| IC50 | 2600±n/a nM |
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| Citation |  Koch, U; Attenni, B; Malancona, S; Colarusso, S; Conte, I; Di Filippo, M; Harper, S; Pacini, B; Giomini, C; Thomas, S; Incitti, I; Tomei, L; De Francesco, R; Altamura, S; Matassa, VG; Narjes, F 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem49:1693-705 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50153250 |
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| n/a |
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| Name | BDBM50153250 |
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| Synonyms: | 5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid | 5,6-dihydroxy-2-(2-thienyl)pyrimidine-4-carboxylic Acid | 5,6-dihydroxy-2-(thiophen-2-yl)pyrimidine-4-carboxylic acid | CHEMBL181653 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H6N2O4S |
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| Mol. Mass. | 238.22 |
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| SMILES | OC(=O)c1nc([nH]c(=O)c1O)-c1cccs1 |
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| Structure | 
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